What is Lymphoma?

Lymphoma is a type of cancer that affects lymphocytes, the disease-fighting cells within our lymphatic system. This system, composed of organs throughout the body, is crucial for our immune response.

In lymphoma, lymphocytes develop abnormally and multiply uncontrollably. These abnormal cells can spread throughout the body, often accumulating in lymph nodes – small, bean-shaped organs that filter lymphatic fluid. This accumulation causes the lymph nodes to enlarge.

Lymphoma encompasses various subtypes, each with its own growth rate. Some are slow-growing, while others are aggressive and fast-growing. In some cases, a slow-growing lymphoma can transform into a more aggressive form. 

Depending on the microscopic appearance of these cancerous lymphocytes, they can be broadly divided into two types of lymphomas, Hodgkin and non-Hodgkin Lymphoma. This is based on the types of cells.

Table of Contents

Diagnostic Tests

If your doctor suspects lymphoma, they will perform a physical exam, ask about your symptoms, and likely order additional tests, such as:

  • Lymph node biopsy: A small sample is taken from an enlarged lymph node and examined under a microscope to check for lymphoma cells.
  • Bone marrow biopsy: A sample of bone marrow, the spongy tissue inside some bones, is extracted and analysed for the presence of lymphoma cells.
  • Other biopsies: In some cases, biopsies may be taken from other suspicious areas to look for lymphoma involvement.
  • Imaging tests: CT scans, PET scans, and other imaging techniques create detailed pictures of the inside of your body, helping to identify any abnormal growths or areas of lymphoma spread.

Understanding Lymphoma Staging

Lymphoma staging is a way for doctors to determine the extent of the disease within the lymphatic system and throughout the body. This staging system helps guide treatment decisions.

Treatment Considerations

The most appropriate treatment approach for lymphoma depends on several factors, including:

  • The specific type and stage of lymphoma
  • Your age and overall health
  • The presence of any other medical conditions

Treatment Approaches

Lymphoma treatment varies depending on factors like the specific type, its growth rate, and the individual’s overall health. While some individuals require immediate treatment, others with slow-growing, asymptomatic lymphoma may initially opt for a watch-and-wait approach.

Common lymphoma treatments include:

  • Chemotherapy: Powerful drugs that target and destroy rapidly dividing cells, including cancer cells.
  • Immunotherapy: These medications enhance the body’s natural immune response to specifically target and eliminate lymphoma cells.
  • Radiation therapy: High-energy rays are used to kill cancer cells in a targeted area.
  • Transplant: This procedure replaces damaged bone marrow with healthy stem cells, often after high-dose chemotherapy or radiation.
  • Replacement of damaged bone marrow with self or donor’s bone marrow cells
  • Chimeric Antigen Receptor T cell therapy– This innovative immunotherapy harnesses the power of the patient’s own immune system.

Life After Treatment

Following treatment, regular check-ups are crucial to monitor for any signs of lymphoma recurrence. These visits may involve physical exams, blood tests, and imaging scans.

It’s essential to be aware of potential lymphoma symptoms and report any concerns to your doctor promptly.

Managing Relapse

If lymphoma returns, your doctor will discuss further treatment options, which may include additional rounds of chemotherapy, immunotherapy, radiation, or transplant.

Active Participation in Your Care

Throughout your lymphoma journey, open communication with your healthcare team is vital. Do not hesitate to ask questions about your treatment plan, potential benefits and risks, alternative options, and consider the following factors:

  • Potential benefits: Will it improve survival, alleviate symptoms, or both?
  • Potential risks and side effects: What are the possibilities, and how can they be managed?
  • Alternative treatments: Are there other approaches to consider?
  • What if I choose no treatment: What are the potential implications?

Remember, you are an active participant in your healthcare decisions. By staying informed and engaged, you can navigate your lymphoma journey with greater confidence.

Disclaimer:

The information on the Centre For Clinical Haematology website is intended for educational use. It should not be considered or used as a substitute for medical advice, diagnosis or treatment from a qualified health professional.

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